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TISSUE INHIBITOR OF METALLOPROTEINASE-1
Descriptors Found:
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DeCS
Descriptor
English
:
Tissue Inhibitor of Metalloproteinase-1
Descriptor
Spanish
:
Inhibidor Tisular de Metaloproteinasa-1
Descriptor
Portuguese
:
Inibidor Tecidual de Metaloproteinase-1
Synonyms
English
:
TIMP-1
Tree Number:
D12.776.645.875.450
Definition
English
:
A member of the
family
of
TISSUE INHIBITOR OF METALLOPROTEINASES
. It is a N-glycosylated protein,
molecular weight
28 kD, produced by a vast range of cell types and found in a variety of
tissues
and
body fluids
. It has been shown to suppress
metastasis
and inhibit tumor invasion in vitro.
Pharmacological Action:
Matrix Metalloproteinase Inhibitors
History Note
English
:
98; see TISSUE-INHIBITOR OF METALLOPROTEINASE-1 (NM) 1980-97
Allowable Qualifiers
English
:
AD
administration & dosage
AE
adverse effects
AG
agonists
AN
analysis
AI
antagonists & inhibitors
BI
biosynthesis
BL
blood
CF
cerebrospinal fluid
CS
chemical synthesis
CH
chemistry
CL
classification
CT
contraindications
DF
deficiency
DE
drug effects
EC
economics
GE
genetics
HI
history
IM
immunology
IP
isolation & purification
ME
metabolism
PK
pharmacokinetics
PD
pharmacology
PH
physiology
PO
poisoning
RE
radiation effects
SE
secretion
ST
standards
SD
supply & distribution
TU
therapeutic use
TO
toxicity
UL
ultrastructure
UR
urine
Record Number:
33426
Unique Identifier:
D019715
Occurrence in VHL
:
Similar:
DeCS
CID-10
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